What Is Longevity

Nutrition and Diet

Eating approaches mapped to longevity: intermittent fasting, ketogenic, carnivore, Mediterranean, anti-inflammatory, and elimination diets among them. What each includes, what is avoided, and who each pattern actually suits.

Topics in Nutrition and Diet

Anti-Inflammatory Diet

An anti-inflammatory diet emphasizes whole foods that reduce chronic low-grade inflammation, a driver of aging and disease. Mechanisms, foods, and evidence.

Autoimmune Protocol (AIP)

The Autoimmune Protocol (AIP) is an elimination diet designed to reduce immune-driven inflammation by removing common dietary triggers, then reintroducing them systematically.

Bone Broth

Bone broth is a slow-simmered stock rich in collagen, amino acids, and minerals. Learn how it supports gut lining, joints, and connective tissue integrity.

Caloric Restriction

Caloric restriction reduces daily energy intake below ad libitum levels to slow biological aging, with decades of evidence from animal models and emerging human data.

Carnivore Diet

The carnivore diet eliminates all plant foods in favor of animal products. Learn how it works, what the evidence shows, and who may benefit.

Electrolytes

Electrolytes are minerals that carry electrical charge in the body, governing hydration, nerve signaling, and muscle function. Here is how they work and what to consider.

Elimination Diet

An elimination diet removes suspected trigger foods, then reintroduces them one at a time to identify reactions affecting digestion, energy, and inflammation.

Fasting-Mimicking Diet

The fasting-mimicking diet provides limited calories over five days to trigger fasting pathways while still eating. Mechanisms, evidence, and how to start.

Fermented Foods

Fermented foods supply live microbes and bioactive compounds that reshape gut ecology, influence immune function, and reduce systemic inflammation.

Glycemic Index

The glycemic index ranks carbohydrates by how fast they raise blood sugar, shaping insulin response and metabolic health over time.

Glycemic Load

Glycemic load measures how much a real-world serving of food raises blood sugar, combining carbohydrate quality and quantity into a single practical number.

Histamine Intolerance

Histamine intolerance occurs when the body cannot break down histamine efficiently, causing symptoms that mimic allergies. Here is how it works and what to eat.

Hydration for Performance

Hydration for performance depends on fluid volume, electrolyte balance, and timing. Learn the mechanisms, what to track, and how to hydrate for training and recovery.

Intermittent Fasting

Intermittent fasting cycles between eating and fasting windows to influence metabolism, autophagy, and insulin signaling. Mechanisms, protocols, and evidence explained.

Juicing

Juicing extracts liquid from fruits and vegetables, concentrating vitamins and phytochemicals while removing fiber. Here is what the evidence shows.

Ketogenic Diet

The ketogenic diet shifts fuel metabolism from glucose to ketone bodies, with implications for insulin signaling, inflammation, and cellular aging pathways.

Lectins

Lectins are carbohydrate-binding proteins found in many plant foods. Learn how they affect digestion, gut permeability, and inflammation, plus how to reduce exposure.

Low-FODMAP Diet

The low-FODMAP diet reduces fermentable carbohydrates that trigger digestive distress, with a structured elimination and reintroduction process backed by clinical evidence.

Meal Spacing

Meal spacing refers to the intervals between eating occasions. Learn how these gaps influence insulin, autophagy, and metabolic health over time.

Meal Timing

Meal timing aligns food intake with circadian biology to influence metabolism, insulin sensitivity, and cellular repair. Here is what the evidence shows.

Mediterranean Diet

The Mediterranean diet centers on olive oil, fish, vegetables, and whole grains, with strong evidence linking it to reduced cardiovascular disease and longer healthspan.

Mold-Free Diet

A mold-free diet eliminates foods likely to contain mycotoxins or promote fungal growth, reducing the toxic burden on sensitive individuals.

Nose-to-Tail Eating

Nose-to-tail eating uses the entire animal, including organs, bones, and connective tissue, to supply nutrients rarely found in muscle meat alone.

Organic vs. Conventional Food

Organic vs. conventional food compared on pesticide residues, nutrient content, and long-term health outcomes, with practical guidance on when organic matters most.

Oxalates

Oxalates are organic compounds in many plant foods that can bind minerals, form kidney stones, and affect nutrient absorption. Here is what the evidence shows.

Paleo Diet

The paleo diet models eating on pre-agricultural foods: meat, fish, vegetables, fruits, and nuts while excluding grains, legumes, and processed foods.

Post-Workout Nutrition

Post-workout nutrition provides the raw materials muscles need for repair and glycogen replenishment after exercise, shaping how well you recover and adapt.

Pre-Workout Nutrition

Pre-workout nutrition provides the substrates muscles need for energy, endurance, and recovery, covering timing, macronutrient balance, and what the evidence supports.

Prolonged Fasting (Extended Water Fast)

Prolonged fasting means consuming only water for 48 hours or more, triggering autophagy, ketosis, and metabolic shifts with real risks to understand first.

Protein Optimization

Protein optimization matches intake amount, timing, and source quality to your body's needs for muscle preservation, repair, and healthy aging.

Protein Timing

Protein timing refers to the strategic distribution of protein intake across the day to optimize muscle protein synthesis, recovery, and long-term body composition.

Seed Oils

Seed oils are refined vegetable oils high in omega-6 fatty acids. Learn how they affect inflammation, oxidation, and metabolic health.

Time-Restricted Eating

Time-restricted eating limits daily food intake to a defined window, aligning nutrition with circadian biology to influence metabolism, autophagy, and aging.

Latest News in Nutrition and Diet

Nature AgingMar 6, 2026

Dietary restriction in aging and longevity

Dietary restriction demonstrates geroprotective effects across species through multiple molecular pathways, though human data remains inconsistent and mechanistic understanding incomplete. This class of intervention represents a critical reference point for evaluating longevity strategies, particularly in identifying which downstream mechanisms drive aging resistance versus which reflect caloric reduction alone.

Longevity.TechnologyMar 4, 2026

Mimio Health trial shows fasting‑mimetic delivers benefits without dieting

Mimio Health's fasting-mimetic therapy produced biomarker changes consistent with fasting physiology—including improved metabolic markers and enhanced fat metabolism—without dietary modification. The intervention was well tolerated and represents a pharmacological approach to accessing metabolic benefits traditionally associated with caloric restriction.

Longevity.TechnologyMar 11, 2026

Fasting mimetic shows metabolic effects in trial

A randomized controlled trial of a fasting mimetic formulation in overweight older adults with elevated HbA1c showed reductions in LDL particle number, oxidized LDL, and fasting glucose over eight weeks. The compound—a blend of spermidine, nicotinamide, palmitoylethanolamide, and oleoylethanolamide—reproduced several cardiometabolic signatures associated with fasting without dietary restriction, though durability beyond the study period remains undemonstrated.

LifeSpan.ioApr 8, 2026

The Timing of Meals Matters for Biological Aging

Meal timing correlates with biological aging rates across multiple organs, with optimal outcomes occurring when the first meal is consumed before 8 a.m. and the last meal between 3 p.m. and 7 p.m., while extended feeding windows and late first meals accelerate aging markers in the heart and liver. This relationship varies substantially by age, sex, and metabolic health status, suggesting meal timing functions as a modifiable variable in aging trajectories.

Nature AgingApr 13, 2026

Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging

Caloric restriction reduces circulating C3a, a complement protein that drives inflammaging in aged tissues. This identifies a specific immunometabolic pathway through which moderate energy restriction extends healthspan in humans.

Wiley Aging CellMar 9, 2026

Correction to “An Ad Libitum‐Fed Diet That Matches the Beneficial Lifespan Effects of Caloric Restriction but Acts via Opposite Effects on the Energy‐Splicing Axis”

A correction to a study examining how ad libitum feeding can extend lifespan through mechanisms opposite to caloric restriction, particularly involving energy-splicing pathways. This finding challenges the assumption that caloric restriction is the only dietary approach to lifespan extension and suggests multiple metabolic routes can achieve similar longevity outcomes.