What Is Longevity

Gut Health

The microbiome, gut-brain axis, leaky gut, SIBO, candida, parasites, and the testing and restoration protocols used to rebuild digestive function. Why so many systemic issues trace back to the gut.

Topics in Gut Health

Akkermansia Muciniphila

Akkermansia muciniphila is a gut bacterium that maintains the intestinal mucus barrier, influences metabolism, and shapes immune signaling. Here is what the evidence shows.

Butyrate

Butyrate is a short-chain fatty acid produced by gut bacteria that fuels colon cells, regulates inflammation, and supports intestinal barrier integrity.

Candida Overgrowth

Candida overgrowth occurs when the fungal yeast Candida expands beyond its normal niche in the gut, triggering immune and digestive dysfunction.

Celiac Disease

Celiac disease is an autoimmune condition where gluten triggers intestinal damage, impairing nutrient absorption and accelerating systemic inflammation.

Fecal Microbiota Transplant (FMT)

Fecal microbiota transplant (FMT) transfers a healthy donor's gut bacteria to restore microbial balance, with evidence for recurrent infections and emerging research beyond.

GERD (Gastroesophageal Reflux Disease)

GERD occurs when stomach acid repeatedly flows into the esophagus, causing tissue damage over time. Learn the mechanisms, signals, and restoration approaches.

Gut Microbiome

The gut microbiome is the community of trillions of microorganisms in your intestines that shapes digestion, immunity, and aging. Here is how it works.

Gut Restoration Protocols

Gut restoration protocols are structured approaches to repair intestinal lining, rebalance microbial communities, and resolve digestive dysfunction from the root.

Gut-Brain Axis

The gut-brain axis is the bidirectional communication network linking intestinal microbes to brain function, influencing mood, cognition, and systemic inflammation.

H. Pylori

H. pylori is a stomach bacterium linked to ulcers, chronic inflammation, and nutrient malabsorption. Learn how it works, how to test, and what to do about it.

IBD (Crohn's and Ulcerative Colitis)

IBD encompasses Crohn's disease and ulcerative colitis, chronic inflammatory conditions of the digestive tract with systemic effects on aging and longevity.

IBS (Irritable Bowel Syndrome)

IBS is a chronic functional gut disorder affecting motility and visceral sensation. Learn what causes it, how to decode symptoms, and restoration approaches.

Leaky Gut (Intestinal Permeability)

Leaky gut occurs when the intestinal lining loses its selective barrier function, allowing molecules into the bloodstream that normally stay confined to the gut.

Microbiome Testing

Microbiome testing analyzes the bacteria, fungi, and other organisms in your gut. Here is how it works, what current evidence supports, and how to interpret results.

Parasite Testing

Parasite testing identifies intestinal and systemic parasitic infections through stool analysis, blood work, or specialized panels, with guidance on accuracy and next steps.

Short-Chain Fatty Acids

Short-chain fatty acids are metabolites produced by gut bacteria from dietary fiber, fueling colon cells and regulating inflammation, immunity, and metabolism.

SIBO (Small Intestinal Bacterial Overgrowth)

SIBO occurs when bacteria overpopulate the small intestine, causing bloating, malabsorption, and systemic effects. Mechanisms, testing, and restoration explained.

SIFO (Small Intestinal Fungal Overgrowth)

SIFO is fungal overgrowth in the small intestine, causing bloating, nausea, and digestive distress. Learn the mechanisms, testing, and restoration approaches.

Stool Testing (GI-MAP / GI Effects)

Stool testing like GI-MAP and GI Effects profiles gut bacteria, parasites, fungi, and digestive markers to guide targeted gut restoration strategies.

Vagus Nerve and the Gut

The vagus nerve is the primary neural link between gut and brain, regulating digestion, immune signaling, and inflammation through bidirectional communication.

Zonulin

Zonulin is a protein that regulates tight junctions in the intestinal lining, directly controlling gut permeability. Learn how it works and what elevated levels mean.

Latest News in Gut Health

The Conversation - LongevityFeb 18, 2026

Your gut microbes can be anti-aging – scientists are uncovering how to keep your microbiome youthful

Gut microbiome composition predicts biological age and directly influences aging trajectories. Maintaining microbial diversity through dietary fiber and exercise represents a measurable pathway to extend healthspan, with fiber supplementation associated with 20–37% improvements in healthy aging outcomes.

Longevity.TechnologyMar 16, 2026

Gut microbes may influence GLP-1 drug response

Gut microbial composition significantly influences individual response to GLP-1 medications, with distinct bacterial patterns correlating to treatment efficacy and the ability of the microbiome to support metabolic signaling. This mechanism explains variable clinical outcomes and suggests microbiome profiling could predict responders before treatment initiation.

Longevity.TechnologyApr 14, 2026

Gut health, autoimmunity and the diet dilemma

Dr. Terry Wahls demonstrates that reframing chronic disease management from treatment to cellular infrastructure—with diet as the primary lever—can produce measurable functional recovery in progressive autoimmune conditions. Her work challenges the assumption that certain diseases are irreversible by restoring gut microbial balance and improving cell-level function through nutritional design.

Nature AgingMar 3, 2026

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice

Transplanting gut microbiota from aging female mice into young adults restored ovarian hormone profiles, follicle development, and fertility markers, establishing a causal relationship between age-related changes in the microbiome and ovarian function decline. This demonstrates that microbiota composition directly regulates reproductive capacity independent of chronological age.

LifeSpan.ioMay 7, 2026

How Intestinal Aging Encourages Harmful Bacteria

Intestinal aging creates a self-reinforcing cycle where the gut barrier weakens, immune function declines, and harmful bacteria replace beneficial species. This shift compromises the production of short-chain fatty acids and other metabolites that support immune regulation, accelerating mucosal dysfunction and systemic inflammation with advancing age.

LT WireMar 18, 2026

Parallel Health unveils skin microbiome mapping technology

Parallel Health has developed Metabolic Microbiome Profiling, a technology that maps the functional output of skin microbes rather than merely identifying species presence. This approach links microbial metabolite production—including vitamins, antioxidants, and short-chain fatty acids—to skin aging phenotypes, enabling personalized dermatological intervention based on actual biochemical activity rather than microbial composition alone.