What Is Longevity

Men's Health

Testosterone optimization, prostate health, andropause, fertility, and the longevity considerations specific to male hormonal physiology and aging trajectory.

Featured Library in Men's Health

PresentationFeb 11, 2026

The 800lb Gorilla: How EDCs Are Destroying Your Hormones

Carlos Bertonatti and Dr. Rudolph Eberwein from Medical Health Institute confront an urgent crisis in modern health: endocrine-disrupting chemicals (EDCs) are systematically destroying hormonal health across all age groups. This panel discussion tackles the "800-pound gorilla" that the functional medicine community often avoids—the root cause of widespread testosterone deficiency affecting men as young as 18. Drawing from their Miami-based hormone optimization clinic, they expose how changing demographics of hypogonadism reveal a generation under siege from environmental toxins, and why addressing this crisis demands immediate action from the biohacking community.

ArticleJan 24, 2026

Why Your Hormones Hold the Key to Thriving Through Midlife

Discover how adaptogenic herbs and alkaline nutrition can transform your midlife experience. Dr. Anna Cabeca's functional approach helps women navigate hormonal shifts with energy, clarity, and confidence.

PresentationFeb 9, 2026

Anna Cabeca Menopause Mood and Mojo

Join Dr. Anna Cabeca, founder of The Girlfriend Doctor, for an empowering session on reclaiming vitality during menopause. Discover how hormonal optimization can transform your mood, energy, and overall well-being during midlife transitions. Dr. Cabeca will share evidence-based strategies for balancing hormones naturally, addressing common challenges like brain fog, weight gain, and emotional fluctuations. Learn practical biohacking techniques to not just survive menopause, but thrive through it with renewed confidence and vitality.

Topics in Men's Health

Andropause

Andropause is the gradual decline of testosterone and other hormones in aging men, affecting energy, body composition, mood, and sexual function.

Aromatase Inhibitors (Male)

Aromatase inhibitors reduce estrogen conversion in men by blocking the enzyme that transforms testosterone into estradiol, with clinical uses and risks explained.

BPH (Benign Prostatic Hyperplasia)

BPH is the non-cancerous enlargement of the prostate gland that affects most aging men. Learn the hormonal drivers, symptoms, and functional approaches to management.

DHT (Dihydrotestosterone)

DHT is the androgen derived from testosterone that drives male sexual development, prostate growth, and hair loss. Mechanisms, testing, and management explained.

Erectile Dysfunction (Functional Approach)

Estrogen Management (Male)

Estrogen management in men involves monitoring and adjusting estradiol levels to support testosterone function, body composition, and long-term health.

Free Testosterone vs Total Testosterone

Free testosterone and total testosterone measure different fractions of the same hormone. Understanding the distinction changes how low testosterone is diagnosed and treated.

HCG Therapy (Male)

HCG therapy in men stimulates testicular testosterone and sperm production. Learn how it works, when it is used, and what the clinical evidence shows.

Late-Onset Hypogonadism

Late-onset hypogonadism is a clinical decline in testosterone production that occurs with aging, affecting energy, body composition, and metabolic health in men.

Low Testosterone

Low testosterone affects energy, body composition, mood, and longevity. Learn the mechanisms behind declining levels and evidence-based approaches to address them.

Male Fertility Optimization

Male fertility optimization addresses sperm quality, hormonal balance, and lifestyle factors that influence reproductive capacity, with evidence on what actually works.

Male Pattern Baldness (Androgenetic Alopecia)

Male pattern baldness results from DHT sensitivity in genetically predisposed hair follicles. Learn the mechanism, hormonal drivers, and evidence on interventions.

Men's Hormone Optimization

Men's hormone optimization addresses age-related hormonal decline through testing, lifestyle changes, and targeted therapies to preserve vitality and healthspan.

Prostate Health

Prostate health covers the gland's role in male reproductive function, how it changes with age, and what evidence supports screening and prevention strategies.

PSA Testing (Prostate-Specific Antigen)

PSA testing measures prostate-specific antigen in the blood to screen for prostate cancer and track prostate health, with key context on accuracy and limitations.

SHBG (Sex Hormone Binding Globulin)

SHBG is a liver protein that binds sex hormones and determines how much testosterone and estrogen remain available to tissues. Here is what your levels mean.

Sperm Quality Testing

Sperm quality testing evaluates concentration, motility, morphology, and DNA integrity to assess male fertility and reproductive health over time.

Testosterone Replacement Therapy

Testosterone replacement therapy restores testosterone to physiological levels in men with clinical deficiency, affecting body composition, cognition, and aging.

Latest News in Men's Health

Peter Attia MDApr 18, 2026

Prostate cancer: a PSA on PSA

Prostate-specific antigen (PSA) screening remains an underutilized tool for early prostate cancer detection despite proven capacity to identify disease at more treatable stages. The clinical evidence supports selective screening in men at appropriate risk, yet implementation barriers persist in clinical practice.

Wiley Aging CellMay 5, 2026

From “Passive Supplementation” to “Active Repair”: Melatonin Reshapes the Treatment Paradigm for Late‐Onset Hypogonadism by Targeting Leydig Cell Senescence

Melatonin restores testosterone production in aging Leydig cells by addressing oxidative stress and mitochondrial dysfunction, offering a mechanism-based alternative to passive testosterone supplementation. This shift from symptom management to cellular repair has implications for age-related hormonal decline in men.

Nature - npj AgingApr 18, 2026

Global stagnation and misaligned priorities in BPH drug development: a 25-year landscape analysis of clinical trial registries

Benign prostatic hyperplasia drug development has stagnated over 25 years, with clinical trial pipelines showing minimal innovation and priorities misaligned with patient burden. This stagnation reflects a broader market failure in addressing age-related conditions that affect quality of life and functional independence in aging populations.

Peter Attia MDApr 20, 2026

#388 — Prostate cancer screening: why current PSA guidelines are failing men and how modern tools improve early detection and save lives

Current PSA-based prostate cancer screening protocols miss clinically significant cancers and fail to distinguish aggressive from indolent disease, reducing detection effectiveness. Modern biomarkers and imaging technologies enable earlier identification of aggressive tumors when intervention is most effective, fundamentally altering outcomes for men at risk.

Wiley Aging CellApr 16, 2026

Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone

Middle-aged and older men with low testosterone demonstrate reduced mitochondrial respiration and decreased SIRT3 expression in vascular endothelial cells, indicating accelerated vascular aging through impaired oxidative stress regulation. This mechanism links testosterone deficiency directly to cardiovascular disease risk through mitochondrial dysfunction.

Wiley Aging CellMay 3, 2026

Loss of Chromosome Y Associates With Altered Immune Cell Trajectories and X‐Inactivation Features

Loss of chromosome Y in male leukocytes, detected in nearly 9% of cells in older men, produces cell-type-specific immune dysfunction characterized by altered monocyte differentiation and aberrant X-chromosome inactivation patterns. These molecular changes associate with increased risk for cardiovascular disease and cancer, suggesting LOY represents a meaningful driver of age-related immune decline in men rather than a neutral age-related marker.