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Testing and Diagnostics

Testing and Diagnostics Library

Every article, presentation, spotlight, and news item we've tagged to Testing and Diagnostics.

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Showing 121–144 of 156

LifeSpan.ioApr 8, 2026

The Timing of Meals Matters for Biological Aging

Meal timing correlates with biological aging rates across multiple organs, with optimal outcomes occurring when the first meal is consumed before 8 a.m. and the last meal between 3 p.m. and 7 p.m., while extended feeding windows and late first meals accelerate aging markers in the heart and liver. This relationship varies substantially by age, sex, and metabolic health status, suggesting meal timing functions as a modifiable variable in aging trajectories.

LT WireApr 22, 2026

BioAge reports positive Phase 1 data for BGE-102

BGE-102, an oral NLRP3 inhibitor, demonstrated rapid and substantial reductions in high-sensitivity C-reactive protein (85–86% median reduction) and inflammatory markers in a Phase 1 trial, with 87–93% of treated participants normalizing hsCRP levels and no serious adverse events reported. This early evidence suggests a therapeutic approach to systemic inflammation that may have relevance to age-related disease prevention.

Wiley Aging CellMar 20, 2026

Age‐Like Methylation Changes of HSCs in GADD45B Knockout Mice Define Methylation Sites Associated With Loss of Function

GADD45B deletion induces DNA methylation patterns resembling age-associated changes in hematopoietic stem cells, yet these methylation alterations occur without functional decline. The research distinguishes between methylation signatures and actual loss of HSC capacity, providing a resource to identify which methylation sites causally drive age-related hematopoietic dysfunction.

LifeSpan.ioFeb 4, 2026

Association Between Vitamins and Slower Biological Aging

A large epidemiological analysis of 15,050 participants found that higher intake of vitamins, particularly C and B2, correlates with slower biological aging as measured by multiple aging biomarkers. The association remained significant after adjustment for socioeconomic and lifestyle factors, suggesting a direct relationship between vitamin adequacy and the rate of biological aging.

Wiley Aging CellFeb 27, 2026

Modifying Role of Sustainable Diets on the Association Between Particulate Matter and Biological Aging: The Guangzhou Biobank Cohort Study

Higher PM 2.5 and PM 10 exposure accelerates biological aging markers in older adults, but adherence to plant-based dietary patterns significantly attenuates this acceleration. The protective effect is strongest in individuals with genetic predisposition to shorter lifespan.

Nature - npj AgingFeb 14, 2026

MicroRNA profiles in plasma-derived extracellular vesicles across the human lifespan

Plasma extracellular vesicles carrying microRNAs show age-specific expression patterns that correlate with biological aging across the human lifespan. These circulating biomarkers may serve as measurable indicators of systemic aging processes and inform stratification of longevity risk.

Nature - npj AgingApr 6, 2026

Biomarkers of oxidative damage as a tool to investigate frailty syndrome in older women

Oxidative damage biomarkers correlate with frailty in older women, providing measurable indicators of cellular stress that precede functional decline. Identifying these markers enables earlier intervention before frailty manifests clinically.

Longevity.TechnologyFeb 20, 2026

Fallopian tube cancer market growth driven by targeted therapies

This article reports on pharmaceutical market expansion in fallopian tube cancer treatment through targeted therapies and companion diagnostics, driven by improved genetic testing for BRCA1/BRCA2 mutations and earlier detection. The development of biomarker-driven, personalized approaches addresses a rare gynecologic malignancy where prevention and early intervention now have clinical pathways.

Longevity.TechnologyFeb 27, 2026

IFN-γ emerges as a simple blood clue to Alzheimer’s

Interferon-gamma (IFN-γ), a common immune signaling molecule, emerges as a blood-based biomarker capable of distinguishing Alzheimer's disease from healthy aging with high accuracy, particularly in individuals carrying the APOE ε4 genetic variant. The finding suggests a scalable pathway for early detection and monitoring, shifting the disease profile toward immune-driven pathology.

Wiley Aging CellApr 14, 2026

Cell Type‐Specific Expression of p16, p21, and p53 Reveals Age‐Dependent Glial Senescence in the AppNL‐G‐F Mouse Model of Alzheimer's Disease

Microglial and astrocytic cells in an Alzheimer's disease mouse model exhibit progressive senescence linked to amyloid pathology, while neurons remain unaffected. This cell-type-specific senescence signature identifies glial cells as primary targets for senescence-directed therapeutic intervention in Alzheimer's disease.

LT WireMar 11, 2026

C2N Diagnostics partners with Codex Genetics to expand Alzheimer’s testing in Hong Kong

C2N Diagnostics and Codex Genetics are expanding access to PrecivityAD2, a blood test measuring amyloid biomarkers to assess Alzheimer's risk in asymptomatic or early-symptomatic individuals. Early detection via non-invasive biomarker assessment enables intervention before cognitive decline becomes clinically apparent, shifting Alzheimer's management from reactive to preventive.

LT WireMar 11, 2026

Gordian Bio unveils scalable in‑vivo screening platform preprint

Gordian Bio describes a scalable in-vivo mosaic screening platform that uses barcoded CRISPR libraries and single-cell readouts to establish causal gene-disease relationships in living organisms. This approach accelerates therapeutic target discovery by testing multiple genetic perturbations simultaneously, reducing experimental variation and improving efficiency compared to traditional methods.

Nature AgingFeb 24, 2026

Identification of distinct and shared biomarker panels in different manifestations of cerebral small-vessel disease through proteomic profiling

Proteomic analysis identifies distinct and overlapping protein signatures across different manifestations of cerebral small-vessel disease, revealing shared involvement of vascular, immune, and neuronal pathways. Plasma protein panels show predictive capacity for cerebrovascular events, establishing measurable biomarkers for disease stratification and risk assessment.

Nature - npj AgingFeb 6, 2026

Similar minds age alike: an MRI similarity approach for predicting age-related cognitive decline

Brain structural similarity patterns on MRI predict individual rates of cognitive decline better than chronological age alone, suggesting that neural architecture itself encodes aging trajectories. This offers a measurable biological marker for identifying cognitive vulnerability before clinical decline becomes apparent.

Wiley Aging CellApr 17, 2026

Telomerase Knockout in Myeloid Cells Predisposes Mice to Foam Cell Formation, Dyslipidemia, Lung Fibrosis, and Cardiac Dysfunction

Telomerase (TERT) in myeloid cells prevents senescence and pro-inflammatory polarization through mechanisms independent of telomere length. Loss of myeloid TERT drives foam cell formation, dyslipidemia, pulmonary fibrosis, and cardiac dysfunction—establishing TERT as essential for preventing aging-associated multi-organ pathology.

Longevity.TechnologyFeb 16, 2026

Aging enters the Parkinson’s lab

Preclinical Parkinson's research has relied on young animal models and acute toxin paradigms that fail to capture the disease's age-dependent biology. The PD-AGE roadmap calls for aging-integrated models—using genetic systems with gradual phenotypes and crossing them with accelerated aging strains—to better reflect how Parkinson's actually develops in older humans and improve translational reliability.

LifeSpan.ioApr 8, 2026

The Timing of Meals Matters for Biological Aging

Meal timing significantly influences biological aging rates, with earlier first meals (before 8 a.m.) and last meals between 3 p.m. and 7 p.m. associated with slower aging in heart, liver, and whole-body measures. The relationship is nonlinear and depends on age, sex, caloric intake, and organ-specific responses.

Nature AgingApr 3, 2026

The case for space as a model of accelerated aging

Spaceflight stressors including microgravity and radiation accelerate biological aging pathways in astronauts, providing a compressed model for studying age-related disease mechanisms. This natural experiment offers direct evidence of how extreme environmental conditions trigger aging processes that occur more gradually in terrestrial populations.

SAGE Research on AgingApr 8, 2026

Multifaceted Declines in Everyday Decision-Making in Older Adults: A Think-Aloud Study

Older adults exhibit measurable declines in everyday decision-making driven by sensory and cognitive changes, with environmental design and support structures demonstrating capacity to mitigate these effects. This directly impacts functional independence and quality of life across the lifespan.

Nature AgingApr 10, 2026

Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence

Single-cell immune profiling across nearly 1,000 adults reveals sex-specific patterns of immune aging, with females demonstrating more extensive age-related remodeling of immune function. These findings establish a biological basis for observed sex differences in inflammatory disease prevalence and infection susceptibility across the lifespan.

Longevity.TechnologyFeb 24, 2026

FDA rewrites drug approval rules and longevity stands to gain

The FDA has shifted its drug approval standard from requiring two pivotal clinical trials to accepting one, citing advances in biological understanding, biomarker validation, and trial design sophistication. This regulatory change has direct implications for aging-related therapeutics, where slow biological processes and prevention-focused interventions have historically faced approval barriers under the two-trial requirement.

Nature AgingFeb 12, 2026

Virtual assistant enhances health outcomes in older adults with type 2 diabetes

A randomized controlled trial found that older adults with type 2 diabetes using a conversational AI virtual assistant achieved significantly better glycemic control and medication adherence compared to standard care. The intervention demonstrates that digital tools can reduce barriers to diabetes management in aging populations.

Peter Attia MDApr 25, 2026

There is no safe gamble with high LDL cholesterol

High LDL cholesterol carries cardiovascular risk regardless of body composition or metabolic phenotype. The concept of "lean mass hyper-responders"—individuals who gain muscle while maintaining low body fat despite elevated LDL—does not eliminate the atherogenic potential of circulating lipoproteins.

Longevity.TechnologyFeb 27, 2026

Measuring intrinsic capacity at scale

Stanford-led THRIVE coalition secured $34.5 million to develop the first FDA-grade Intrinsic Capacity score, a composite measure integrating wearables, blood biomarkers, and functional assessments to predict 20-year health outcomes. This addresses the field's critical gap: the absence of regulatory-grade measurement infrastructure for aging itself, moving beyond disease-specific endpoints toward quantifiable functional decline.