Testing and Diagnostics Library

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Showing 97–120 of 157

Wiley Aging CellMay 6, 2026

Healthy Eating Index, Epigenetic Age Acceleration and Mortality Risk in US Adults

Higher diet quality correlates with slower epigenetic aging and reduced mortality risk in two large U.S. cohorts, with epigenetic age acceleration (GrimAgeEAA) explaining approximately 44% of the diet-mortality association in one cohort. The relationship is partially confounded by physical activity and integrated lifestyle factors, indicating that diet operates within a broader system of behavioral and biological aging pathways rather than in isolation.

Longevity.TechnologyFeb 27, 2026

A cellular atlas of aging comes into focus

A single-cell chromatin atlas across 21 tissues reveals that aging involves coordinated, sex-specific regulatory remodeling rather than random molecular decay. The coordinated shifts across anatomically distinct organs suggest systemic drivers—circulating signals, immune tone, endocrine cues—offering both mechanistic insight and practical constraints for intervention design.

Longevity.TechnologyMar 12, 2026

AI predicts who will decline faster in Alzheimer’s

Machine learning models trained on routine clinic data predict individual rates of cognitive and functional decline in Alzheimer's disease and mild cognitive impairment with greater accuracy than population averages. Early identification of specific functional vulnerabilities—such as difficulty with finances or meal preparation—enables targeted interventions before independence is lost.

Wiley Aging CellApr 27, 2026

Short‐Term Dietary Intervention Alters Physiological Profiles Relevant to Ageing

A 4-week dietary intervention in adults aged 65–75 reduced KDM-derived biological age estimates, with the greatest effects seen in high-carbohydrate and semi-vegetarian groups. This rapid shift in composite biomarkers suggests diet produces measurable physiological changes relevant to aging trajectories, though longer-term data are needed to establish impact on disease risk.

Nature AgingMar 6, 2026

A glycolytic metabolite puts the brakes on cGAS-driven aging

Phosphoenolpyruvate, a glycolytic metabolite, suppresses cGAS-driven inflammation through a direct molecular interaction. The age-related decline in PEP availability explains the transition from metabolic stability to chronic inflammation and neurodegeneration.

Nature - npj AgingApr 6, 2026

HCCaging: a liver physiological aging-related biomarker for hepatocellular carcinoma diagnosis based on transcriptome data

Researchers identified HCCaging, a transcriptome-based biomarker that reflects liver aging patterns and improves hepatocellular carcinoma diagnosis. This tool bridges the gap between cellular aging processes and cancer risk stratification, offering earlier detection potential before advanced disease.

LT WireFeb 20, 2026

Human Longevity launches personal AI‑powered longevity app

Human Longevity has released an AI-powered mobile app that analyzes biometric, lifestyle, and genetic data to generate personalized health recommendations across nutrition, exercise, sleep, and preventive care. The platform's utility depends on the quality of data interpretation and user adherence to recommendations over time.

Longevity.TechnologyMar 17, 2026

Roche gets CE mark for Alzheimer’s risk blood test

Roche has obtained CE mark approval for a blood test that identifies ApoE4 carriers, a genetic variant associated with increased Alzheimer's risk. This test streamlines risk stratification and treatment planning by enabling clinicians to prioritize patients for further evaluation and guide therapeutic decisions, particularly regarding amyloid-targeting therapies that carry differential risk profiles based on ApoE4 status.

Nature - npj AgingApr 14, 2026

The retina-body axis: proteomic mechanisms linking oculomics and clinical traits in a female aging cohort

Retinal protein signatures correlate with systemic aging markers and clinical traits in women, establishing the eye as a window into whole-body physiological age. These oculometric measures may enable earlier detection of aging-related dysfunction across multiple organ systems.

Wiley Aging CellFeb 5, 2026

Sex Differences in Associations Between Adversity and Biological Ageing

Childhood adversity associates with accelerated biological aging markers primarily in women, while adulthood adversity shows stronger associations with aging markers in men. This sex-specific pattern suggests distinct windows of physiological vulnerability across the lifespan that warrant consideration in aging research and clinical intervention timing.

Nature AgingApr 29, 2026

Multimodal data analysis reveals asynchronous aging dynamics across female reproductive organs

Deep learning analysis of histological and transcriptomic data from over 300 female donors reveals that reproductive organs age asynchronously rather than in lockstep, with menopause functioning as a critical inflection point detectable in circulating protein signatures. This challenges the assumption of synchronized aging across organ systems and identifies tissue-specific vulnerability windows relevant to longevity and disease prevention.

Longevity.TechnologyFeb 19, 2026

Clair Health launches wearable hormone intelligence

Clair Health has launched a non-invasive wearable that uses multimodal biosensors and AI to infer continuous hormonal patterns across the female lifespan, moving beyond episodic blood tests and calendar-based tracking. The device collects skin temperature, heart rate variability, sleep, and breathing data as proxies for endocrine state, positioning hormonal monitoring as a prevention tool rather than a fertility marker.

Nature - npj AgingFeb 13, 2026

Association of brain age gap with BMD and incident fractures in the UK Biobank

Accelerated brain aging—measured as the difference between chronological age and brain imaging markers—correlates with lower bone mineral density and increased fracture risk independent of chronological age. This suggests neurobiological aging patterns may predict skeletal fragility and fracture vulnerability in midlife and older adults.

Longevity.TechnologyFeb 6, 2026

Telomir Pharmaceuticals reports new data on epigenetic modulation mechanism

Telomir-1 (Telomir-Zn) modulates intracellular metal balance by increasing zinc and reducing iron, influencing epigenetic regulation and cellular stability without triggering cytotoxic stress. This mechanism addresses oxidative stress and genomic integrity pathways implicated in aging and cancer biology.

Nature AgingMar 10, 2026

Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age

Microglia—the brain's resident immune cells—exhibit distinct transcriptional patterns and morphological changes with age, with subcellular mRNA localization directly influencing their functional capacity. This work establishes how aging alters the molecular foundation of neuroinflammation, a process central to cognitive decline and neurodegenerative disease progression.

Longevity.TechnologyApr 2, 2026

Agentis, Ultrahuman tie wearables to Longevity Quotient

Agentis Longevity and Ultrahuman have integrated continuous glucose monitoring and wearable biomarker data into a clinical scoring system (Longevity Quotient) designed to bridge the gap between real-time metabolic data and actionable preventive care. The partnership addresses low engagement in preventive health practices by making personalized, data-driven interventions accessible at scale.

Nature - npj AgingFeb 26, 2026

From wrist data to lifespan: elucidating inflammation-driven biological aging via activity rhythms captured by wearable devices

Wearable devices tracking activity rhythms reveal that irregular movement patterns correlate with systemic inflammation and accelerated biological aging. This connection between circadian disruption and aging rate offers a quantifiable marker for longevity risk that precedes clinical disease.

Nature AgingMar 6, 2026

The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging

Phosphoenolpyruvate, a glycolytic metabolite, suppresses cGAS-STING-driven inflammation and improves cognitive function in Alzheimer's disease models while correlating with healthy aging markers in humans. This identifies a metabolic checkpoint that regulates innate immune signaling during aging.

Longevity.TechnologyFeb 17, 2026

New functional brain assessment system rolls out in the US

QuantalX Neuroscience has launched Delphi MD, an FDA-cleared non-invasive system that quantifies real-time functional brain network activity using transcranial magnetic stimulation, electroencephalography, and AI analytics. This technology enables clinicians to detect subtle changes in brain function before structural damage or cognitive decline becomes apparent, shifting neurological care from reactive symptom management to preventive assessment.

Wiley Aging CellMay 6, 2026

Estimating Vascular Age to Evaluate the Association Between Aging and Cardiovascular Disease

Vascular age acceleration, measured through a quantitative model, independently predicts cardiovascular disease risk beyond chronological age, with a 21–25% increased risk in those showing accelerated vascular aging. This metric enables earlier identification of individuals requiring intervention before overt disease manifestation.

Longevity.TechnologyFeb 9, 2026

Twenty years on, cognitive training shows dementia signal

A 20-year follow-up of the ACTIVE trial found that speed-of-processing training with booster sessions reduced dementia diagnoses in older adults, a rare signal of efficacy in prevention research anchored to clinical diagnoses rather than cognitive test scores alone.

Longevity.TechnologyMar 4, 2026

Mimio Health trial shows fasting‑mimetic delivers benefits without dieting

Mimio Health's fasting-mimetic therapy produced biomarker changes consistent with fasting physiology—including improved metabolic markers and enhanced fat metabolism—without dietary modification. The intervention was well tolerated and represents a pharmacological approach to accessing metabolic benefits traditionally associated with caloric restriction.

Nature - npj AgingFeb 20, 2026

Are levels of DHEAS indicative of subjective health – results of the population-based longitudinal CARLA study

Dehydroepiandrosterone sulfate (DHEAS) levels correlate with subjective health perception in a longitudinal population study, suggesting this adrenal steroid may serve as a physiological marker for how individuals experience their own health status. The finding bridges objective biochemistry with subjective well-being, relevant to understanding which biomarkers meaningfully predict health experience across the lifespan.

Nature - npj AgingMar 20, 2026

Electrocardiogram derived heart age models agreement, accuracy and predictive ability in the Tromsø study

Electrocardiogram-derived heart age models show moderate agreement with chronological age but demonstrate significant individual variation, with predictive accuracy for cardiovascular outcomes varying substantially depending on the specific model used. This suggests ECG-based age estimates require careful interpretation and cannot yet replace traditional risk assessment tools.

Biological EDGE

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