IgG N-glycome patterns independently predict all-cause mortality across 20,405 individuals and respond to intervention, meeting established criteria for a valid aging biomarker. Therapeutic plasma exchange produced the largest reduction in glycan age at 0.4 years per month, positioning glycan structure as both a mechanistic link to chronic inflammation and a measurable target for lifespan extension.
Key Points
- IgG glycome independently predicts mortality across 42 studies
- Therapeutic plasma exchange reduces glycan age 0.4 years/month
- Glycan patterns mechanistically link inflammation to disease risk
Longevity Analysis
Glycan structure serves as a molecular readout of systemic inflammation and immune aging that precedes overt disease. The validation of this biomarker across tens of thousands of individuals establishes a measurable target for intervention. Therapeutic plasma exchange's capacity to reverse glycan age suggests that removing circulating factors driving chronic inflammation can measurably shift aging trajectories — a finding with direct implications for practitioners seeking to interrupt inflammatory cascades before they propagate into multiple disease states.
Original published by Longevity.Technology.