A platelet membrane-coated resveratrol nanoparticle system activates FOXM1 to restore mitochondrial function and reverse endothelial senescence in atherosclerosis models. The approach addresses both the bioavailability limitations of resveratrol and the cellular dysfunction underlying vascular pathology.
Key Points
- PM@RSV nanoparticles activate FOXM1, restoring mitochondrial ATP and reducing oxidative stress
- Endothelial senescence markers decreased; vascular regeneration promoted in atherosclerotic lesions
- Platelet membrane coating enables targeted delivery to damaged endothelium via adhesion proteins
Longevity Analysis
Atherosclerosis progression depends on two interrelated failures: mitochondrial dysfunction that starves cells of energy and regenerative capacity, and endothelial senescence that impairs vascular repair. This research demonstrates a mechanistic pathway—FOXM1 activation—that simultaneously addresses both failures. For individuals managing cardiovascular aging, the finding suggests that restoring mitochondrial efficiency and clearing senescent endothelial cells are not separate problems but interconnected processes that respond to a single regulatory lever. The delivery mechanism matters as much as the molecule; targeting damaged tissue rather than systemic distribution increases efficacy while reducing off-target effects.
Original published by Wiley Aging Cell, by Li Xiao, Zexin Zhan, Ping Liu, Bing Qin .